Fallout 2 builds8/2/2023 ![]() Equipping a lockpick would improve Lockpicking skill, Motion sensor improves Outdoorsman skill and Tool improves Repair skill. Some skills can be improved while having certain items equipped. Note: Don`t invest in First Aid, Science, Repair, and Outdoorsman skills because you can increase those via books (Comprehension perk reccomended) up to a maximum of 91% skill value. Energy Weapons (must have for the late game).You should also consider tagging energy weapons instead of lockpicking since you don't need high lockpicking once you find a lockpicking set. Small Guns (via Books until you reach 91%) 1 Hat8 7:03am Small frame is a pretty cruddy gunslinger skill.or Good Natured (+15% to First Aid, Doctor, Speech, and Barter / -10% to Big Guns, Small Guns, Energy Weapons, Throwing, Melee Weapons, and Unarmed) - Will be very difficult at the beginning! (note: at least 1-2 companions recommended to fight for you at the early stages of the game).or Small frame (+1 AG / Carry Weight = 25 + (15 x your Strength) - 1 extra point but less carry weight! (note: if you gonna pick Small frame then you need at least 1 companion to carry your stuff).Finesse (+10% Critical chance / -30% total damage) - Critz! (note: with high LK and a few Perks you can increase your crit chance up to 25%).Gifted (+1 to all SPECIAL stats / -10% to all skills, 5 less skill points per level) - Must have!.Note: If you like to play without companions invest in EN 8 and in CH 3. LK 5 (+2 Zeta scan in Vault City, +2 when You kill Pharias dog from special random encounter, +1 Perk).AG 8 (+1 Perk) Restoration Project req: +1 AG - EPA, +1 AG - New Reno - Going on a date with Miss Kitty As a consultant, I'm often brought in to work with organizations where trust is low and the toxic fallout is beginning to affect the whole organization.IN 8 (+1 Chip - Sierra Army Depot, +1 Perk) Best Games of 2023 All Game Deals Are you searching for the hottest sales on the site Look no further than Top Sellers You can find all the hottest offers on games, bundles, eBooks and software.CH 5 (+1 Chip - Navarro, +1 Perk, +1 when you have sunglasses - Mason form Salvatores have them or dig them from the grave in the Golgotha). ![]() PE 8 (+1 Chip - Mariposa Military Base, +1 Perk).ST 4 (+4 Advanced Power Armor, +1 Chip - Vault 8, +1 Perk).These perk cards give you different abilities and bonuses and can be upgraded by combining cards of the same type together to increase whatever bonus they give.Gender and age are largely irrelevant unless you plan on seducing lots of NPC's. Each point you spend in a stat gives you, in essence, another slot that you can fit a perk card into. By level 50, you'll have gotten all of the skill points that you're going to get (and probably some mutations along the way, and though they're going to be left out of this build guide, they can be useful tools for a build), leveling out at 56 points to spread across the seven different stats. Welcome to the Platinum Collection for June 2023, featuring some of the most enjoyable Steam PC games around including nine NEW-TO-BUNDLE titles. Plenty of players are still making their way through the Appalachians in the post-apocalypse of Fallout 76, and at this point, many of those players have gathered the max amount of points to spend on their S.P.E.C.I.A.L. ![]() ![]() (Updated on December 27th, 2019 with five more builds to include updates to Fallout 76)
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Wireshark alternative8/2/2023 If 'netsh trace' has solved an interesting problem for you, or was the tool that got you some interesting data in a pentest, please, use our comment form to let us know how you used it (within your NDA of course!) This Powershell cmdlet is not available in Windows 7 - you'll need Windows 8, or Server 2008 or newer $s | Add-PefMessageProvider -Provider “C:\input\path\spec\Input.etl” $s = New-PefTraceSession -Path “C:\output\path\spec\OutFile.Cap” -SaveOnStop A short, simple script to do this might look like: Or you can convert to PCAP using PowerShell (of course you can). If you do need another packet analysis tool, it's easy to a File / Save As / Export, and save as a PCAP file that Wireshark, tcpdump, SNORT, ngrep, standard python or perl calls, or any other standard tool can read natively. Message Analyzer has a surprisingly nice interface and some decent packet parsing, you might be able to wrap up your analysis just in this tool (see below). ![]() ![]() Next, open the file (which is in Microsoft's ETL format) in Microsoft's Message Analyzer app - which you can install on your workstation rather than the server we ran the capture on ( ). If this is a pentest, a standard copy might still work (remember, we're on a Microsoft server), but if you need netcat type function to exfiltrate your capture, take a look at PowerCat (which is a netcat port in PowerShell). If this is a capture for standard sysadmin work, you can simply copy the capture over to your workstation and proceed on with analysis. If all you have is a metasploit shell, netsh trace works great! The cool thing about this is that it doesn't need a terminal session (with a GUI, cursor keys and so on). Tracing session was successfully stopped. "C:\Users\Administrator\AppData\Local\Temp\NetTraces\NetTrace.cab".įile location = C:\Users\Administrator\AppData\Local\Temp\NetTraces\NetTrace.etl The trace file and additional troubleshooting information have been compiled as When you are done capturing data, it's time to stop it: Trace File: C:\Users\Administrator\AppData\Local\Temp\NetTraces\NetTrace In a pentest you would likely specify an output file that isn't in the users' directory.Ĭ:\>netsh trace start capture=yes IPv4.Address=192.168.122.2 Note that you need admin rights to run this, the same as any capture tool. ![]() You could also add Protocol=TCP or UDP and so on.įull syntax and notes for netsh trace can be found here: įor instance, the following session shows me capturing an issue with a firewall that I'm working on. ' netsh trace start capture=yes Ethernet.Type=IPv4 IPv4.Address=157.59.136.1' ![]() One of the examples in this output shows you how t o e.g. We'll need to filter the capture, usually to a specific host IP, protocol or similar. Of course, in most cases, tracing everything on any production box is not advisable - especially if it's your main Exchange, SQL or Oracle server. Show - List interfaces, providers and tracing state. Type "netsh trace help" on any Windows 7 Windows Server 2008 or newer box, and you'll see the following:Ĭonvert - Converts a trace file to an HTML report.Ĭorrelate - Normalizes or filters a trace file to a new output file. And yes, it does exactly what it sounds like it does. Well, as they say in networking (and security as well), there's always another way, and this is that way. Have you ever been on a pentest, or troubleshooting a customer issue, and the "next step" was to capture packets on a Windows host? Then you find that installing winpcap or wireshark was simply out of scope or otherwise not allowed on that SQL, Exchange, Oracle or other host? It used to be that this is when we'd recommend installing Microsoft's Netmon packet capture utility, but even then lots of IT managers would hesitate about using the "install" word in association with a critical server. Tumblr naked models8/2/2023 ![]() That’s just one of the ideas at play in Kelly Reichardt’s quietly extraordinary drama Showing Up. Stay in that zone too long and there’s a danger of forgetting how to have a simple conversation or make a phone call, of going a little feral. ![]() ![]() Making anything of value-a work of art, a poem, a solid piece of furniture-demands a deep descent into the self, to the point that it’s easy to neglect the needs of others in your orbit. But in surfing the wave of Brontë’s unknowability, O’Connor ultimately reaches a kind of emotional truth, one that chimes with the ideas this enigmatic writer folded into the prose of her only book. Is this really how Wuthering Heights came to be? Almost certainly not. But the spark that truly ignites her imagination is an intensely erotic but ill-fated love affair with the young curate hottie, William Weightman (Oliver Jackson-Cohen), who has come to assist her father in the parish. Emma Mackey plays Emily, the sheltered and eccentric daughter of an uptight Yorkshire curate, growing up with siblings-including the competitive, passive-aggressive Charlotte (Alexandra Dowling)-who help shape the writer she’ll eventually become. But Frances O’Connor’s directorial debut, which blends fact with fanciful fiction, paints a haunting and sympathetic portrait of the person Emily Brontë might have been. We know very little about the woman who wrote Wuthering Heights, one of the great gothic novels, a story of melancholic obsession and of love that seeps into the soil of the grave. This is a movie about how the most joyful moments of our lives are sometimes entwined with the worst, a state of uneasy grace that’s as close as you can get to a happy ending. It doesn’t matter that Georg has always been a little distant as a father Sandra must still do her best to care for him, whatever “her best” might be. She needs some joy in her life: her father, Georg (Pascal Greggory), suffers from a neurodegenerative disease that has already robbed him of his sight and is now, increasingly, blurring his mind. She’s been alone for a long time, but she tumbles into a kind of happiness after a chance encounter with an old friend, Clément (Melvil Poupaud), turns into an illicit affair. Léa Seydoux is Sandra, a widowed translator living in Paris with her eight-year-old daughter. But it’s also about the difficulty-and the necessity-of tending to our own emotional lives even as we’re looking after others. Writer-director Mia Hansen-Løve’s delicately shaded One Fine Morning deals with the wrenchingly mundane nature of caring for those who used to take care of us. Somewhere between the right and the wrong decision is the choice we learn to live with, a sea of joy and sadness and everything in between. The movie ripples with the quiet melodrama of real life, the way big things often happen in the margins, and small things gradually come to mean the world. There are no villains here no one lashes out or behaves badly. Song has said the story she tells in Past Lives is semiautobiographical, and that’s easy to believe. When Hae Sung shows up in New York, Nora begins to wonder if she’s made all the right choices in her life, asking the kinds of questions that can knock anyone’s world off its axis. She’d been close friends with him in childhood, before she and her family emigrated from South Korea to Canada they’d reconnected briefly as adults, if only via Skype, but a romance seemed impossible. In Celine Song’s extraordinary debut film, Nora ( Greta Lee), a playwright living in New York, married happily enough to fellow writer Arthur (John Magaro), finds her world rattled when a man from her past, Teo Yoo’s Hae Sung, suddenly re-enters her orbit. Malanda’s radiantly somber face, held by the camera with a kind of inquisitive tenderness as she tells her story on the stand, is the heart of the picture. This is a perceptive and delicately unnerving work, a reflection on the way humans can instinctively reach out to one another even across seemingly uncrossable chasms. But as she listens to Laurence’s story, she begins to see the web of experience and feeling that connects her with her subject. Rama’s plan is to gather material for an updated retelling of Medea. Rama (Kayije Kagame), a professor and novelist, travels from Paris to the town of Saint-Omer to attend the trial of a woman named Laurence Coly (Guslagie Malanda), accused of an unthinkable crime that she doesn’t deny. From that story, Diop has extracted a picture that’s both poetic and compassionately direct. French documentary filmmaker Alice Diop’s first fiction feature is based on a real-life French court case involving a Senegalese immigrant who left her 15-month-old daughter on a beach to die. Georgia expo manufacturing peach pit8/2/2023 ![]() Hanson’s Scott Dickson, for example, has identified several opportunities at the workshop for his plant managers and supervisors. While GCAA producer members had the opportunity in February to visit with 88 exhibitors, the number of producer attendees has grown largely because of the educational program the association offers. Click to enlarge | Photo: Tom Smarch Photography With 11 new associate members at GCAA, the number of exhibitors participating in the expo leapt to a record 88. “That’s why we have exhibitors outside the ballroom.” Finding value “We had 11 new exhibitors in one year,” Glaze says. A number of exhibits now spill into a major hallway that attendees navigate anyway to reach the main ballroom. ![]() The GCAA Management Workshop & Expo now has so many participating exhibitors that it recently outgrew a Cobb Galleria Centre ballroom that long housed all of the booth spaces. Once they started doing that, we followed here in time.” “As an associate member, we want to see the president and all of his VPs, but we also want to see the plant manager, the foremen and the people who make decisions. “People have classified this as the ‘mini Con/Agg,’” Glaze says. More producers are sending their leaders, particularly the decision-makers suppliers seek out. “It became an international workshop about five or six years ago.”Īggregate industry suppliers are ultimately drawn to the GCAA event because aggregate producers see the value. “Companies from all over the world are represented here – from Ireland, Germany, France, Europe, Spain, China,” says Glaze, a dealer whose company is classified as an associate member of GCAA. That’s high praise for a show whose producer members are confined within the Peach State’s borders. Glaze, who has put 47 years into the industry and now sits on the GCAA board of directors, characterizes the event as a true international workshop. Click to enlarge | Photo: P&Q Staffĭoug Glaze, the CEO at NorX, has also seen the GCAA Management Workshop & Expo blossom across multiple decades. Having put in nearly a half-century to the industry, NorX’s Doug Glaze has experienced the evolution of the GCAA Management Workshop & Expo more than anyone. There’s a lot of growth and opportunity here.” If you build it, they will come “I feel like it’s a pretty well-run event,” he says, “but it shows you how Atlanta and Georgia have grown. Jeff Wansley, the executive director of GCAA who joined the association in 2015, attributes the show’s growth to a couple of key factors. It is a record, and it’s really a lot of people when you think about this small area.” We registered 20 people or so and about 15 on-site. “About three weeks prior to, we were right around 600. “Last year, we had about 575 total attendees,” Moore says. Eleven exhibitors participated in GCAA’s workshop for the first time.Īll of these numbers represented single-year records for the workshop. 19-20 at the Cobb Galleria Centre in Atlanta, drew more than 650 people and featured 88 exhibitors. All we had was a program and name badges – that was it.”Ĭonsider, then, just how far the GCAA Management Workshop & Expo has come in Moore’s 31-plus years. “It was tiny, and I thought it was big at the time. “Everything I put into the show went into one box,” says Moore, who continues to serve GCAA today as member services manager. As she recalls, the 1989 event included about five vendors and probably fewer than 50 people attended. It was February 1989, and Moore had just joined the GCAA staff two months earlier. Linda Moore vividly remembers the very first Georgia Construction Aggregate Association (GCAA) Management Workshop & Expo she took part in. More than 650 people participated in the GCAA Management Workshop & Expo back in February, setting a new high for attendees. Incredibles kronos unveiled download8/2/2023 ![]() ![]() It is obvious that the creators of The Incredibles wanted a new version of the Barry Bond sound, and if Barry himself couldn’t provide it, they made sure they hired someone who could. When John Barry, the original composer attached to the film, suddenly declined the picture on the grounds of not wanting to re-hash his old style of music, Pixar ushered in Giacchino to fill his shoes. Jackson, Jason Lee and Wallace Shawn.īest of all, from our point of view, the film’s high profile worked wonders for the career of Michael Giacchino, as it was, in effect, his first “big screen” score. The Incredibles was one of the box office hits of 2004, receiving rave reviews for its retro look, intelligent writing, action-packed storyline, adult in-jokes, stunning animation, and voice cast, which also included Samuel L. That is, however, until a new evil villain threatens his world, and he and his family are forced to abandon their new lives and become super heroes once more. Now living in suburbia with his wife Helen aka Elastigirl (Holly Hunter), and his three super-hero kids, Bob increasingly finds his life boring and unfulfilling. Incredible was forced into the witness protection programme, and made to conceal his true identity from everyone. However, when one too many law suits came his way, Mr. Incredible, the world’s foremost and most popular super-hero, for whom saving the world was a daily exercise. Nelson), an ordinary joe in an ordinary 9-to-5 job who harbours a surprising secret: 10 years ago, Bob was Mr. We follow the story of Bob Parr (Craig T. The Incredibles is most definitely in Pixar’s top 10 films – an exciting action-adventure superhero/spy romp with generous helpings of humour related to middle-class suburban existence, directed by former Simpsons contributor Brad Bird. Rochard gere8/2/2023 The officer has Rudy taken back to Max and coerces Max to beat Rudy to death. Another prisoner on the train, wearing a pink triangle patch, explains the patch system during the Holocaust to Max and tells Max that he must show no sentiment towards Rudy. Rudy is beaten within an inch of his life, all the while Max tries to ignore his screams. The officer makes Rudy crush his glasses, and then orders Rudy to be taken, presumably to be killed for his poor eyesight. On the train, Rudy is spotted wearing glasses by an officer. They are forced to board a train headed for Dachau concentration camp. As a result, Max and Rudy are found in a forest tent-colony and arrested by the Gestapo. ![]() Max's uncle Freddie, who is also gay, but lives a more discreet life with rent boys to satisfy his desires, has organized new papers for Max to flee to France where homosexuality is legal, but Max refuses to leave Rudy behind. She officially fires Rudy and hands Max the finder's fee she earned from the SS. Greta explains that the SS approached her for information about Wolf, and that she took them to Max and Rudy's apartment. Greta is a drag-queen she ran her own gay club, which is newly shut down (implicitly due to, at the time, new Paragraph 175 enforcements). They seek counsel from Rudy's boss Greta. Wolf is discovered the next morning and killed by SS men in Max and Rudy's apartment, and the two have to flee their home. Unfortunately, it is the night that Hitler orders the assassination of the upper echelon of the Sturmabteilung corps, to consolidate his power. One evening, much to the resentment of his boyfriend Rudolph Hennings (Rudy), he brings home a handsome Sturmabteilung man, Wolfgang Granz (Wolf). Maximilian Berber (Max), a promiscuous gay man in 1930s Berlin, is at odds with his wealthy family because of his homosexuality. ![]() In some regards, the play helped increase that historical research and education in the 1980s and 1990s. When the play was first performed, there was only a trickle of historical research or even awareness about the Nazi persecution of homosexuals. The title of the play refers to the slang word "bent" used in some European countries to refer to homosexuals. It revolves around the persecution of gays in Nazi Germany, and takes place during and after the Night of the Long Knives. Persecution of homosexuals in Nazi Germanyīerlin, 1934 following the Night of the Long Knivesīent, sometimes stylised as BENT, is a 1979 play by Martin Sherman. ![]() The veteran actor is known for his best of all romance and comedy dramas.Poster for the Royal National Theatre's 1990 revival of Bent, starring Ian McKellen Maybe I do come six years after Richard Gere’s last feature film credit in the 2017 drama Three Christs.įor the unversed, Richard Gere is known for hit films like An Officer and a Gentleman (1982), Chicago (2002), Days of Heaven (1978), Arbitrage (2012), Unfaithful (2002), Intersection (1994), Sommersby (1993) & Pretty Woman (1990). The film explores the events after a young couple introduces their respective parents to each other only to discover that they are already on rather intimate terms, and Gere likened the film to the 30s and 40s, Hollywood making. Goodbar, while the star-studded cast also includes Susan Sarandon, William H Macy, and Emma Roberts. The movie reunited him with Diane Keaton, who he previously worked with in the 1977 film Looking for Mr. Meanwhile, Richard Gere was recently seen in the film Maybe I Do. This message of universal brotherhood and sisterhood is the one we want to hear again and again.” Richard said on Yoga Day that, “PM Modi is a product of Indian culture and comes from a vast place like Indian culture does. Famed Hollywood actor Richard Gere, Iyengar yoga exponent Deidra Demens, New York City Mayor Eric Adams, and prominent American singer Mary Millben were among the eminent personalities who joined Prime Minister Narendra Modi for a unique yoga session at the UN Headquarters. Hollywood actor Richard Gere, who attended the event, is also an advocate for human rights in Tibet and co-founder of the Tibet House, US, and Chairman of the Board of Directors for the International Campaign for Tibet. The A2 flash hider is also the most common AR 15 muzzle device on the planet, and as such, it’s stupid cheap. Yep, I know it’s a flash suppressor, not a compensator or muzzle brake, so why is it on the list? Well, the A2 birdcage system features five slots that are fairly long and work to not only reduce flash but also reduce recoil and keep the gun low and on target. Two many people sleep on the standard A2 birdcage flash suppressor. Ultradyne Apollo Max Pros and ConsĬheck Latest Price Standard A2 Bird Cage Review Ultradyne makes some high-quality products that are premium tier gadgets, gizmos, and add-ons. The Apollo Max gives shooters a beefy but very capable muzzle device for increasing your control over the gun. It’s certainly designed more for outdoor use than CQB. It’s almost four inches long and makes a standard carbine dang near the size of an M16. The main downside, in fact, the only downside to the Apollo Max, is the length. To add to the recoil-reducing features, a pair of compensating slots sit at the tip of the device. Beyond that, the included timing nut and design of the Apollo MAx make it very easy to install and properly center. Installation isn’t difficult, and a set of wrench flats made applying torque plenty easy. The Ultradyne Apollo Max will make your weapon even easier to control, and it works very well on shorter-than-average barrel lengths. A standard 5.56 caliber rifle doesn’t deliver a ton of recoil, to begin with, but the Apollo Max takes a good bit of sting out of even that low recoil. You’ll be surprised by how much recoil you can tune out of your rifle with the Apollo Max. The Ultradyne Apollo Max brings you a premium-grade muzzle brake designed from the ground up to maximize performance. It’s big, loud, mean, and will reduce recoil substantially. ![]() I’d like to introduce you to one of the most effective muzzle brakes on the market. Best AR-15 Muzzle Brakes & CompensatorsĬheck Latest Price Ultradyne Apollo Max Review Now that we know what compensators and muzzle brakes do, let’s talk about what are some of the genre-defining options currently on the market. These devices mix in the port of compensators and brakes to pull double duty and offer you the best of both worlds. This leads to the development of hybrid devices. The goals of compensators and muzzle brakes are similar, and one doesn’t negate the benefits of the other. Since recoil is a rearward push, the forward push helps defeat recoil and increase control. It effectively pushes forward on your baffles which creates a push forward effect on your rifle. How? Well, the gas hits the baffles or ports, and this action creates a braking effect. A muzzle brake features a series of side ports and baffles that work to reduce recoil. A muzzle brake redirects gas to reduce recoil and make a rifle more manageable. The good news is that it’s not something designed to make you slow down. The upward-directed gas pushes downward and, by extension, mitigates muzzle rise and improves your control. Naturally, when a weapon recoils, it moves back and upwards.Ī compensator is a precision-made device with cuts that orient upward, and when the gas reaches these cuts, slots, or dots, the gas takes the path of least resistance which is both upward and forward. ![]() It’s a muzzle device that redirects gas upward to push the muzzle downward. It’s not a thing insecure dudes buy to make up for their faults. To skip ahead, you’ll find our Best Muzzle Brakes & Compensator list here. You’ll be a pro on AR compensators and muzzle brakes by the end of this article. We’ll define what each does, point out some of the best on the market, and even go over a few different considerations when selecting a device. There are even different types of muzzle devices, but today we will focus on two specific performance-enhancing muzzle devices, the compensator, and the brake. Muzzle devices in the AR 15 world are vast and plentiful like anything else in the AR 15 world. That threading is ripe for the addition of a muzzle device. At the tip of 99% of AR 15s sits some form of threading. Override do not disturb iphone8/2/2023 The built-in Do not Disturb mode works pretty well on android mobile. It will help you to skip all the other notifications. Just select the app that want to get notifications for and put your phone on that particular mode. But, you can get the same settings for all the other apps you have. In this example, we have used Facebook Messenger. That’s all! Now, you just have to put your phone on Priority only mode that is under Do not disturb. Here, you will get an option called Treat as priority. For that, just tap on that respective icon to open the settings. Suppose, you want to block notifications from Facebook Messenger. ![]() You can find all the apps those show notifications for any reason. ![]() Now, on the next screen, all the installed apps will be listed. Then, scroll down and tap on Do not disturb. At first, open Settings and go to Sound & notification. To allow an app, do follow these subsequent steps. This mode will let you choose whether an app should sound for the notifications or not. As mentioned before, this is one of the best features of Android Marshmallow. This is however very easy with the help of Priority only feature that comes under Do not disturb. Allow Particular App to Show Notifications on Do not Disturb This post will let you show how to put an app on white list so that it can show all the notifications and block others. Therefore, if you are quite time concerning person, who doesn’t want to waste his/her time on social network or doing anything else but, wants to get all important notifications, here you go.
Rimworld update 20188/2/2023 No discussing pirated versions of the game. If you post a screenshot, please point out what you want people to look at in the image or explain in the comments. RimWorld Relevance/Meme & Low-Effort Content Policy. Streams and let's plays may be posted in r/RimWorldStreams If you want to continue playing patch 1.2, youll be able to do so. ![]() Self Promotion: Guides are OK, Let's Plays are not. Update released Posted March 28th, 2023 by Tia Young Spring is here, so we’re springing into action with a (small) update of fixes for RimWorld and its expansions. Tomorrow, Rimworld Ideology and Patch 1.3 (currently in public beta) will release. Absolute NO sexual content involving minors under the age of 18 is allowed, period. Do not discuss details of RJW content in comments unless the post has the TW:RJW flair and NSFW tag. Please add the TW:RJW flair and the NSFW tag to all posts containing RimJobWorld content. Do not link to NSFW content hosted off-site, including mods. Do not misuse the NSFW tag when it's not needed. If you encounter any issues while playing, please share them with us on the Discord. Big thanks to our community for submitting bugs and testing our updates over at the official RimWorld development Discord. Heres someone with a lightsaber, about to beat the shit out of a giant sloth. ![]() ![]() This update should be compatible with all savegames and mods. And even when it seemed those were at an end with the 1.0 release at the end of 2018, its modder-friendly design kept the party going until last weeks surprise release, not just of Royalty, but of a free 1.1 update too, with its own substantial feature list. Maintain an atmosphere of respect and never personally attack anyone.Īll posts containing sexual content or realistic nudity must be tagged NSFW in both comments and posts. Hi folks We have a pretty small update with just a few changes and fixes to get 2023 started. Reddit's Content Policy must be observed at all times. Official subreddit for the console version! Buy RimWorld and the DLCs! 1.4 - Biotech DLC Announcement Live Help Thread Steam Workshop Q&A Threads Fan Art Fan Comics Monthly Subreddit Challenges 2020 HP Interview with Tynan DEV BLOG OFFICIAL SITE OFFICIAL WIKI STEAM PAGE RimWorld FAQ Modding FAQ Non-Official Discordįollow standard reddiquette. Hlh up to date8/2/2023 Ī unique flow cytometric (FCM) finding in Epstein-Barr virus (EBV)-positive HLH patients has been reported: clonal expansion of EBV-infected CD8 + T cells with CD5 or CD7 downregulation. Morphological evaluation of BM aspirates in HLH patients usually shows non-specific abnormal findings such as an increased number of histiocytes and lymphocytes with or without hemophagocytosis and a marked left shift in myelopoiesis. ![]() ![]() Because these clinical and laboratory findings are often present in various diseases, the diagnosis of HLH may be challenging, especially in early stages of disease. It is characterized by fever, splenomegaly, cytopenia, hypertriglyceridaemia, hypofibrinogenemia, low or absent natural killer (NK) cell activity, elevated blood levels of the soluble IL-2 receptor and ferritin, and haemophagocytosis in biopsy samples of bone marrow (BM), spleen or lymph nodes. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome related to excessive immune activation of macrophages and T cells. Keywords: Epstein-Barr virus, Familial, Hemophagocytic lymphohistiocytosis, Flow cytometry, T cell, Overall survival However, it may not be useful as a prognostic marker. ConclusionsĪn aberrant T cell immunophenotype may assist in discriminating EBV-negative secondary HLH and EBV-positive HLH. The presence of an aberrant T cell immunophenotype was not related to overall survival in EBV-positive HLH and EBV-negative secondary HLH patients. Only one (1/15, 6.7%) patient with EBV-negative secondary HLH showed an aberrant loss of CD7 antigen on CD8 + T cells. ResultsĪn aberrant immunophenotype, including CD5 and/or CD7 downregulation on T cells, was observed in 55.6% (15/27) of the EBV-positive HLH patients and 100% of the familial HLH (3/3). Overall survival was estimated using Kaplan-Meier curves and compared using the log-rank test. We retrospectively characterized downregulation patterns of CD5 or CD7 on activated T cells, using flow cytometry. We classified 45 HLH patients into three subgroups: EBV-positive HLH (N=27), EBV-negative secondary HLH (N=15), and familial HLH (N=3). As the utility of T cell immunophenotypes as an adjunctive diagnostic or a prognostic marker for HLH has not been evaluated, we analyzed T cell immunophenotypes in HLH patients for this purpose. Downregulation of CD5 or CD7 on T cells has been reported in patients with Epstein-Barr virus (EBV)-positive HLH. T cell immunophenotypes in patients with hemophagocytic lymphohistiocytosis (HLH) have been described. AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |